Effect of salicylates and other non-steroidal anti-inflammatory drugs on articular cartilage. Gayathri et al. Boswellic acids: Novel, specific, non-redox inhibitors of 5-lipoxygenase. fil.) The resin of Boswellia species (frankincense, olibanum) has been used as incense in religious and cultural ceremonies since time immemorial. However, the pharmacological relevance of such interference in vivo seems questionable[59]. Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. SOME OF THE CHARACTERISTIC FEATURES OF FOUR PENTACYCLIC TRITERPENIC ACIDS (BOSWELLIC ACIDS). Treatment of osteoarthritis with a herbomineral formulation: A double blind, placebo-controlled, cross-over study. Among the boswellic acids, 3-acetyl-11-keto-beta-boswellic acid (AKBA) potently inhibits 5-lipoxygenase product formation with an IC50 of 1.5M. Three renowned ancient texts form the pillars of classical Ayurvedic Science, which has its roots in India: Charaka's Charaka Samhita (c.B.C. [3], Extracts of Boswellia serrata have been clinically studied for osteoarthritis and joint function, with the research showing trends of benefit (slight improvement) in pain and function. 14th ed. Boswellia supplementation did not cause changes in hepatic DNA fragmentation on 30, 60 or 90 days of treatment. Sane RT. in 2011 have reported a simple, rapid, accurate, reproducible, selective and economic HPTLC method for routine quality control analysis as also quantitative determination of -boswellic acid from Boswellia serrata Roxb. Learn more The novel anti-inflammatory properties of the gum resin derived from Boswellia serrata, also known as Salai guggal in Ayurvedic medicine, are well recognized and highly recommended for human consumption. Pang X, Yi Z, Zhang X, Sung B, Qu W, Lian X, et al. It is generally used in making incense powder and sticks. -Boswellic acid can downregulate the synthesis of prostaglandins by inhibiting COX-1 in intact human platelets (Siemoneit et al., 2008). Very recently, Pawar et al. of India; p. 2045. In ancient times, Hindus, Babylonians, Persians, Romans, Chinese and Greeks as well as the people of old American civilizations used natural resins primarily for embalming and for its incense in cultural functions. Effect of salicylate on proteoglycan metabolism in normal canine articular cartilage. Modern medicine and pharmacology strongly point out to its use as an antiarthritic, antiinflammatory, antihyperlipidemic (controls blood lipids), antiatherosclerotic (anticoronary plaque), analgesic (pain-reliever) and hepatoprotective (protects the liver)[15,2124]. The effect of anti-inflammatory drugs on glycosaminoglycan sulphation in pig cartilage. Boswellia, also known as Boswellin or Indian frankincense, comes from the Indian Boswellia serrata tree. Pardhy RS, Bhattacharyya SC. They also inhibit histamine release from MCs challenged with G protein stimulator c48/80 in a dose-dependent manner (Pungle et al., 2003). Encyclopedia of India, Rational Western Therapy, Ayurvedic and other Traditional Usage. In vitro studies and animal models show that boswellic acids were found to inhibit the synthesis of pro-inflammatory enzyme, 5-lipoxygenase (5-LO) including 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB-4), which cause bronchoconstriction, chemotaxis, and increased vascular permeability[3338]. Acetyl-11-keto--boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. The fraction was effective in both adjuvant arthritis (35-59%) as well as established arthritis (54-84%). Boswellia carterii Birdw, grows in Somalia and in the native language it is called moxor and the resin produced is known as luban dhakar. By continuing you agree to the use of cookies.

Processing and Product Development Division, Indian Institute of Natural Resins and Gums, Namkum, Ranchi-834 010, India. Boswellia serrata (family Burseraceae) is commonly found in many regions of the world, such as South Asia, Northern Africa, and the Middle East. Primary skin irritation test was conducted with Boswellia on New Zealand albino rabbits and Boswellia was classified as non-irritating. Out of these four boswellic acids, acetyl-11-keto--boswellic acid is the most potent inhibitor of 5-lipoxygenase, an enzyme responsible for inflammation. Boswellia tree can produce exudates in good quality only for three years. Salai guggul (from. In fact, the time has come when our medicinal discoveries must move in mighty leaps and bounds, if the human race is to be saved from the onslaughts of continuously multiplying maladies. The results revealed that there were significant differences in pharmacokinetic parameters between normal and arthritic groups, and the absorptions of two boswellic acids (11-keto--boswellic acid and 3-O-acetyl-11-keto--boswellic acid) were significantly higher in HLXLD than B. serrata extract alone. We use cookies to help provide and enhance our service and tailor content and ads. Boswellia serrata grows throughout the hotter parts of India. This is available in capsules or tablets, and also in a soothing pain relieving cream containing capsaicin. The resins have a fragrant aroma because of the presence of essential oils and this accounts for their commercial importance. The B. serrata extract has boswellic acids, which provide beneficial health effects. Taken together, these results demonstrate the broad spectrum safety of Boswellia (Lalithakumari et al., 2006). These extracts contain resin, amino acids, phenols, terpenes, polysaccharides, and -boswellic acid, the major active antiinflammatory component. [1], Boswellia serrata is currently at risk of being eradicated because of non-sustainable practices. have reported clinical trials of Boswellia's antiinflammatory properties in combination with Withania somnifera, Zingiber officinate and Curcuma longa and the isolated effects of Boswellia on rheumatoid arthritis could not be revealed[50,51]. The first two pillars of Ayurveda describe the antirheumatic (antiarthritis) activity of gugguls-the gum-resins of trees[1620]. Darkening of colour of resin is also due to autoxidation, polymerization and enzymatic reactions. Baliga, in Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases, 2013. Egyptians were the first to refer the use of Frankincense as an herbal medicine where it was used for the treatment of tumors, inflammatory disorders, and asthma [2]. The Wealth of India, Raw Materials. Acetyl-boswellic acids exhibit anti-inflammatory properties by inhibiting leukotriene synthesis (Ammon et al., 1993). Chiavari G, Galletti GC, Piccaglia R, Mohamud MA. No changes in body weight or adverse effects were observed following necropsy. Boswellic acids in chronic inflammatory diseases. F297001G). Bethesda, MD 20894, Web Policies The antiarthritic potential of BA is reported to be due to its anti-inflammatory activity mediated through inhibition of NF-B, COX-2, and 5-LOX (Takada et al., 2006). London: WB Saunders Company Ltd; 1996. There were few adverse effects. 700), the first fundamental medical text; Susruta's Susruta Samhita (c.B.C. Salai, an oleo gum-resin, is a plant exudate of genus Boswellia (Family: Burseraceae). It is tapped from the incision made on the trunk of the tree, which is then stored in specially made bamboo basket. Certain boswellic acids also inhibit elastase in leukocytes, inhibit proliferation, induce apoptosis, and inhibit topoisomerases in cancer cell lines. Gum-resin extracts of Boswellia serrata have been traditionally used in folk medicine for centuries to treat various chronic inflammatory diseases. Pure compound from, Moussaieff A, Shohami E, Kashman Y, Fride E, Schmitz ML, Renner F, et al. The recommended dosage is based on historical practice or available trials. Derivatives of boswellic acids. government site. The Boswellia serrata plant is native to India, and its extract has been used as a traditional medicine for centuries. Palmowski MJ, Brandt KD. Products containing boswellic acids range from 150-250 mgs/capsules or tablets, and are taken orally two to three times a day. They burned these resins during sacrificial ceremonies and in their daily rituals to prevent the influence of evil spirits on their souls or to honour the dead or living ones[46]. Indian Journal of Pharmaceutical Sciences. In India, the States of Andhra Pradesh, Gujarat, Madhya Pradesh, Jharkhand and Chhattisgarh are the main source of Boswellia serrata. Raychaudhuri and her colleagues described their study as the first to evaluate the efficacy of the extract enriched with a form of boswellic acid on osteoarthritis[61]. The In patients with ulcerative colitis Boswellia serrata 350mg tds for 6 weeks produced improvements in stool properties, histopathology of rectal biopsies, hemoglobin, serum iron, calcium, phosphorus, proteins, and total leukocyte and eosinophil counts, with remission in 82% of patients [3]. The corresponding figure with sulfasalazine 1g tds was 75%. Tetracyclic triterpene acids from the resin of, Pardhy RS, Bhattacharyya SC.

The residue, semi-solid to solid part, is the gum-resin which hardens slowly into amorphous, tear-shaped products with an aromatic scent. Chemical structure of alpha-boswellic acid. Sharma S, Thawani V, Hingorani L. Pharmacokinetic study of 11-keto-beta-boswellic acid. Preparations from the gum resin of Boswellia serrata have been used as traditional remedies in Ayurvedic medicine in India for inflammatory diseases [1]. Rall B, Ammon HP, Safayhi H. Boswellic acids and protease activities. Rocklin, CA: Prima Publishing; 1995. This is the most expensive brand of resin in the market[11]. Acute dermal LD50 of Boswellia was found to be >2,000mg/kg. Choudhary AC, Dikshit SK. Boswellia serrata (Salai/Salai guggul), is a moderate to large sized branching tree of family Burseraceae (Genus Boswellia), grows in dry mountainous regions of India, Northern Africa and Middle East. ScienceDirect is a registered trademark of Elsevier B.V. ScienceDirect is a registered trademark of Elsevier B.V. HHS Vulnerability Disclosure, Help It has been suggested that 5-loxin is safe and well-tolerated in OA. El-Khadem H, El-Shafei ZM, Elsekeify MA, Abdel Rahman MM. Lemenih M, Teketay D. Frankincense and myrrh resources of Ethiopia: II.Medicinal and industrial uses. These have also been used as adhesives, as ingredients for cosmetic preparations, as fragrances in daily rituals and in religious ceremonies, as coating materials and also for their different curative powers[13]. Ammon HP, Safayhi H, Mack T, Sabieraj J. -Boswellic acid, R1=H, R2=H2; acetyl--boswellic acid, R1=Ac, R2=H2; 11-keto--boswellic acid, R1=H, R2=O; acetyl-11-keto--boswellic acid, R1=Ac, R2=O. The resin of Boswellia species has been used as incense in religious and cultural ceremonies and in medicines since time immemorial. Hall, R. Bravo-Clouzet, in Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases, 2013.

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